Q: One advantage of Dronedarone (Multaq) over Amiodarone is removal of iodine moieties from its compound which decreases the side effects to thyroid, lung and nervous system. What other advantage it is said to have over Amiodarone?



Answer: It has much shorter half life.

Dronedarone is less lipophilic and so has an elimination half-life of only 24 hours in contrast to amiodarone which has half life extended over several weeks.